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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
5.45
Human Site:
S398
Identified Species:
8
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
S398
S
N
C
Q
N
K
E
S
A
S
K
Q
S
_
_
Chimpanzee
Pan troglodytes
XP_525364
403
45791
S398
S
N
C
Q
N
K
E
S
A
S
K
Q
S
_
_
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
Dog
Lupus familis
XP_853397
405
45606
D399
S
S
S
Q
K
N
K
D
S
T
S
K
Q
S
_
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
E389
P
T
G
H
T
S
K
E
P
T
S
K
S
S
_
Rat
Rattus norvegicus
P59241
397
44856
E391
P
T
G
H
N
S
K
E
A
T
S
K
S
S
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
Chicken
Gallus gallus
XP_425725
409
46456
T398
V
L
V
H
P
W
I
T
A
N
S
T
K
L
P
Frog
Xenopus laevis
Q91819
408
46443
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
E324
Q
K
R
E
R
G
K
E
N
T
A
R
N
_
_
Honey Bee
Apis mellifera
XP_395732
327
37711
Nematode Worm
Caenorhab. elegans
O01427
305
34731
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
0
14.2
N.A.
7.1
21.4
N.A.
0
6.6
0
0
N.A.
0
0
0
0
P-Site Similarity:
100
100
0
50
N.A.
28.5
42.8
N.A.
0
20
0
0
N.A.
38.4
0
0
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
25
0
7
0
0
0
0
% A
% Cys:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
7
0
0
13
19
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
13
0
0
7
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
19
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% I
% Lys:
0
7
0
0
7
13
25
0
0
0
13
19
7
0
0
% K
% Leu:
0
7
0
0
0
0
0
0
0
0
0
0
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
13
0
0
19
7
0
0
7
7
0
0
7
0
0
% N
% Pro:
13
0
0
0
7
0
0
0
7
0
0
0
0
0
7
% P
% Gln:
7
0
0
19
0
0
0
0
0
0
0
13
7
0
0
% Q
% Arg:
0
0
7
0
7
0
0
0
0
0
0
7
0
0
0
% R
% Ser:
19
7
7
0
0
13
0
13
7
13
25
0
25
19
0
% S
% Thr:
0
13
0
0
7
0
0
7
0
25
0
7
0
0
0
% T
% Val:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
19
38
% _